**Featured in CDC Bulletin** _Mosquitoes have become increasingly resistant to insecticides used for public health, thus compromising mosquito control efforts. However, these processes have not been fully understood. DPDM research demonstrated that insecticide exposure impacts bacteria that colonize mosquitoes (the mosquito microbiota). The presence of insecticide-metabolizing bacteria in resistant mosquitoes could potentially be used to predict insecticide resistance in the field._